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Cannabis can be smoked in a pipe, bong or joint. When inhaled, CBD, THC and other compounds are absorbed by the lungs, into the blood, and cross the blood-brain barrier. The first effects of inhaled cannabis usually occur within a few minutes, and gradually wear off after 2-3 hours. Smoking is often effective for treating acute symptoms that need to be addressed quickly, such as painful spasms, nausea, and vomiting. It is fairly easy to titrate (continuously measure and adjust) the dose by inhaling. If the effect is insufficient after a few minutes, one can take another puff until the desired effect is achieved. But smoke contains noxious substances that may irritate the lungs.